고려대학교 간호대학

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Basic Nursing

Basic Nursing Science - Faculty&Teaching Courses


Geun Hee Seol - Faculty
Name : Geun Hee Seol
Departments : Basic Nursing Science
Room : 510
E-mail : ghseol@korea.ac.kr

Education
Post-Doctoral Fellow in Neuroscience, Mind/Brain Institute, Dept. of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2006
Ph.D. in Physiology, Dept. of Physiology, Ewha Womans University School of Medicine, Seoul, Korea. 2004
M.S. in Physiology, Dept. of Physiology, Ewha Womans University School of Medicine, Seoul, Korea. 2001
B.S. in Nursing, Dept. of Nursing, Korea University School of Medicine, Seoul, Korea. 1996

Professional Experiences
2013-Present: Reviewer for Evidence-Based Complementary and Alternative Medicine
2013-Present: Reviewer for Journal of Alternative and Complementary Medicin
2013-Present: Editor for Korean Journal of Human Development
2012-Present: Reviewer for Neuroscience Letters
2012-Present: Editor and Reviewer for Korean Journal of Stress Research
2012-Present: Education Director for Korean Educational Association of Integrative Medicine
2011-Present: Counselor for Psychologic Affairs from Korea Psychology Counseling Association
2011-Present: Reviewer for Journal of Korean Academy of Nursing
2010-Present: Associate Professor, Dept. of Nursing, Korea University School of Nursing, Korea
2009-Present: Reviewer for Journal of Korean Biological Nursing Science
2007-Present: Reviewer for Journal of Korean Gerontological Nursing
2010-2012: Academic Director for Korean Educational Association of Integrative Medicine
2008-2010: Publication Director for Korean Educational Association of Integrative Medicine
2006-2010: Assistant Professor, Dept. of Nursing, Korea University School of Nursing, Korea
2006-2006: Adjunct Instructor, Dept. of Nursing, Korea University School of Nursing, Korea
2006-2006: Post-doctoral Fellow, Dept. of Physiology, Eulji University School of Medicine, Korea
2004-2006: Post-doctoral Fellow, Mind/Brain Institute, Dept. of Neuroscience, Johns Hopkins University School of Medicine, USA
2002-2003: Adjunct Instructor, Dept. of Nursing, Dankook University School of Medicine, Korea
1996-1998: Nurse, Dept. of Psychiatry, Korean University Anam Hospital

Honors and Awards
Best Teaching (Myoung) Award, Korea University The Graduate School of Education, Spring 2013
Poster Award, Korean Society of Adult Nursing International Conference, 2013
Outstanding Teaching (Seok-tap) Award, Korea University, Fall 2011
Award Certificate, Korean Educational Association of Integrative Medicine, 2011
The Marquis Who’s Who in the World Publications, 2011
Best Teaching (Myoung) Award, Korea University The Graduate School of Education, Spring 2011
Outstanding Teaching (Seok-tap) Award, Korea University, Fall 2010
Outstanding Teaching (Seok-tap) Award, Korea University, Fall 2008
Poster Award, The 13th Congress of the Asian College of Psychosomatic Medicine, 2008

Research Interests
Our laboratory is interested in exploring the cellular and molecular mechanisms of neuronal plasticity underlying learning and memory. Dr. Geun-Hee Seol currently focuses upon the physiological roles of aromatic essential oils in neuronal cells as well as endothelial cells. In more detail, we explore novel biochemical mechanisms of aromatic essential oils which can control brain diseases such as pain and which can also control cardiovascular diseases such as hypertension. Current emphasis of laboratory animal studies focuses upon the experimental analysis of the basic mechanisms of aromatic essential oils with the objective of evaluating compounds. To develop aromatheraphy that has aromatic effect without adverse effects after revealing their mechanisms of action, we also study the action of aromatic essential oils in pain related clinical diseases. In addition, we are also interested in elucidating the role of calcium in the regulation of neuronal plasticity.
Combining various techniques, such as electrophysiology, cellular & molecular biology, calcium imaging and behavioral neuroscience, we are investigating to understand molecule-to-behavior pathways using mice or rats. Main topics of our research include 1) neural mechanisms of learning and memory, 2) action mechanisms of aromatic essential oils, and 3) intracellular calcium signaling.

Research Project as Principal Investigator
2012.5 -2015.4 “Study for the inhibitory effect of aroma on the ischemic brain injury and changes of synaptic plasticity” supported by Basic Science Research Program through National Research Foundation of Korea (NRF: 606,000,000 won / 3yrs)

2010.5 -2013.4 “Study for the mechanism of analgesic effect with aroma in inflammatory pain model” supported by Basic Science Research Program through National Research Foundation of Korea (NRF: 194,527,000 won / 3yrs)

2012.3-2013.2 “Effect of basil-inhalation on pain in patients with chronic low back pain” supported by Nursing Research Institute Grant, Korea University (1,000,000 won / 1yr)

2010.3-2011.2 “Effect of Aroma Essential Oil on Endothelial Ca2+signaling” supported by a Korea University Grant (10,000,000 won / 1yr)

2009.5 -2012.4 “Study for the mechanism of antihypertensive of aroma in vascular tone” supported by Basic Science Research Program through National Research Foundation of Korea (NRF: 139,762,000 won / 3yrs)

2007.5 -2010.2 “Study for the mechanism of anti-depression and anti-stress of aroma” supported by Korean Science and Engineering Foundation (KOSEF: 140,000,000 won / 3yrs)

2006.9-2007.8 “The regulating mechanism of synaptic plasticity in the cerebral cortex” supported by a Korea University Grant (10,000,000 won / 1yr)

2004.4 -2005.3 “A study of correlation between cognitive function and hippocampal LTD in aged rats” supported by Korean Science and Engineering Foundation (KOSEF: 10,000,000 won / 1yr)

Major Publications
(2013) Effects of 1,8-Cineole on Hypertension Induced by Chronic Exposure to Nicotine in Rats, J Pharm Pharmacol .2013 Dec 17. doi: 10.1111/jphp.12195. [Epub ahead of print]
(2013) Citrus bergamia Risso elevated intracellular Ca2+ in human endothelial cells due to release of Ca2+ from primary intracellular stores, Evid Based Complement Alternat Med. 2013(759615): 1-7
(2013) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice, LIFE SCI. 93: 955-961
(2013) Randomized controlled trial for Salvia sclarea or Lavandula angustifolia: Differential effects on blood pressure in female patients with urinary incontinence undergoing urodynamic examination, J Altern Complement Med. 19(7): 664-670
(2013) The essential oil Citrus bergamia Risso induces vasorelaxation of mouse aorta by activating K+ channels and inhibiting Ca2+influx, J Pharm Pharmacol. 65(5): 745-749
(2013) Bergamot essential oil differentially modulates intracellular Ca2+ levels in vascular endothelial and smooth muscle cells: a new finding seen with Fure-2, J Cardiovasc Pharm. 61(4): 324-328
(2013) Effect of eucalyptus oil inhalation on pain and inflammatory responses after total knee replacement: A randomized clinical trial, Evid Based Complement Alternat Med. 2013(502727): 1-7
(2013) Phorbol 12-myristate 13-acetate enhances long-term potentiation through activation of a protein kinase Cδ and ε in hippocampus, Korean J Physiol Pharmacol. 17(1):51-56
(2012) Bryostatin-1 promotes long-term potentiation via activation of PKCα and PKCε in the hippocampus, Neuroscience 226:348-355
(2012) Effect of basil essential oil-inhalation on pain, anxiety and vital sign in patients with chronic low back pain before spine surgery: A double-blind, randomized controlled trial, Korean J Str Res. 20(3):169-178
(2011) Neuregulin-1 prevents amyloid β-induced impairment of long-term potentiation in hippocampal slices via ErbB4, Neurosci Lett. 505(1): 6-9
(2011) Effect of bergamot essential oil-inhalation on chronic pain after surgery for lumbar spinal stenosis, J Korean Biol Nurs Sci. 13(2):156-163
(2011) Effect of clary sage-inhalation on pain and stress during the treatment of periodontitis, J Korean Acad Oral Health. 35(1): 32-40
(2010) Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats, J Ethnopharmacol. 130(1):187-190
(2009) Antinociceptive effects of the essential Oil of Ocimum basilicum in mice, Korean J Pain. 22(3): 206-209
(2009) Inhibition of the N-methyl-D-aspartate receptor unmasks the antinociception of endogenous opioids in the periphery, Pain 143(3): 233-237
(2009) Chronic brain inflammation impairs two forms of long-term potentiation in the rat hippocampal CA1 area, Neurosci Lett. 456(1): 20-24
(2009) Impairment of long-term depression induced by chronic brain inflammation in rats, Biochem Biophys Res Commun. 383(1):93-97
(2008) Effects of intra-articular injection of agmatine and clonidine into the knee joint cavity on the induction and maintenance of arthritic pain in rats, Korean J Anesthesiol. 54(6): 656-661
(2008) The Na+/Ca2+exchanger inhibitor KB-R7943 activates large-conductance Ca2+-activated K+ channels in endothelial and vascular smooth muscle cells, Eur J Pharmacol. 582(1-3): 35-41
(2007) Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity, Neuron 55(6): 919-929
(2007) Factors affecting loneliness in community dwelling Korean elders, J Korean Acad Fundam Nurs. 14(3): 371-381
(2005) Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex, J Neurosci. 25(49): 11433-11443
(2005) Sphingosine-1-phosphate–induced intracellular Ca2+ mobilization in human endothelial cells, Endothelium 12(5) 263-267
(2005) Na+-K+ pump activation inhibits endothelium-dependent relaxation by activating the forward mode of Na+/Ca2+ exchanger in mouse aorta, Am J Physiol Heart Circ Physiol. 289(5): H2020-2029
(2004) Inhibition of endothelium-dependent vasorelaxation by extracellular K+: a novel controlling signal for vascular contractility, Am J Physiol Heart Circ Physiol. 286(1): H329-339
(2004) Characteristics and a functional implication of Ca2+-activated K+ current in mouse aortic endothelial cells, Pflugers Arch. 447(4): 426-435
(2004) Nitric oxide-induced intracellular Ca2+ modulation in macrovascular endothelial cells, Korean Circulation J. 34(9): 600-609
(2004) Regulatory mechanism of vascular contractility by extracellular K+: effect on endothelium-dependent relaxation and smooth muscle contractility, Korean J Thorac Cardiovasc Surg. 37(3): 210-219
(2001) The inhibitory effect of opioid on the hyperpolarization-activated cation currents in rat substantia gelatinosa neurons, Korean J Physiol Pharmacol. 5(5): 373-380

Books
(2013) Color Atlas of Pathophysiology, Seoulmedmedia
(2013) Pathophysiology, Jungmunkag
(2013) Essential of medical terminology, Medicean
(2010) Pharmacology, Jungmunkag
(2009) Human Diseases, Bioscience
(2009) Comprehensive Stress Management, Academia

Teaching Courses
Undergraduate Program:
MRSG 240 Basic Nursing Science I
MRSG 250 Basic Nursing Science Lab I
MRSG 241 Basic Nursing Science II
MRSG 251 Basic Nursing Science Lab II
MRSG 243 Basic Nursing Science III
MRSG 244 Basic Nursing Science IV
MRSG 234 Introduction to Nursing Research
Graduate Program:
MSG 720 Seminar on Basic Nursing Science
MSG 505 Pathophysiology
ENU 619 Quantitative Research in Nursing Education
ENU 564 Advanced Pathophysiology